Plicamycin, also known as mithramycin or Mithracin, is an antineoplastic antibiotic produced by the bacterium Streptomyces plicatus. Plicamycin binds to DNA and inhibits both DNA and RNA synthesis. It accomplishes this by binding to the guanine-cytosine (GC) rich regions of DNA, preventing the transcription of genetic information into RNA. As a result, the synthesis of proteins and other essential cellular components is disrupted.
Researchers may employ plicamycin to investigate its effects on gene expression, cell cycle regulation, and apoptosis in cancer cells.
WARNING! This product can expose you to Pilcamycin, a chemical which is known to the State of California to cause developmental harm. For more information go to www.P65Warnings.ca.gov.